Biofabrication for neural tissue engineering applications

3D biofabrication strategies for tissue engineering and regenerative medicine.

Over the past several decades, there has been an ever-increasing demand for organ transplants. However, there is a severe shortage of donor organs, and as a result of the increasing demand, the gap between supply and demand continues to widen. A potential solution to this problem is to grow or fabricate organs using biomaterial scaffolds and a person's own cells. Although the realization of thi...

Biofabrication of Tissue Scaffolds

Chemically-bound nerve growth factor for neural tissue engineering applications.

In order to promote regeneration after spinal cord injury, growth factors have been applied in vivo to rescue ailing neurons and provide a path finding signal for regenerating neurites. We previously demonstrated that soluble growth factor concentration gradients can guide axons over long distances, but this model is inherently limited to in vitro applications. To translate the use of growth fa...

Auricular reconstruction using biofabrication-based tissue engineering strategies.

Auricular malformations, which impose a significant social and psychological burden, are currently treated using ear prostheses, synthetic implants or autologous implants derived from rib cartilage. Advances in the field of regenerative medicine and biofabrication provide the possibility to engineer functional cartilage with intricate architectures and complex shapes using patient-derived or do...

Biofabrication of gold and silver nanoparticles for pharmaceutical applications

Biofabrication by using fungi is an exciting recent interest to develop an eco-friendly production of metallic nanoparticles (NPs) for pharmaceutical applications. This study aimed to synthesize and characterize gold (Au) and silver (Ag) NPs by using Penicillium simplisimum. The fungus was grown in fluid czapek dox broth on shaker at 28 ºC and 200 rpm for ten days. Then the supernatant was...